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Window of opportunity against HIV comes from 'fitness bottleneck' New research on HIV transmission among heterosexual couples in Zambia shows that viral fitness is an important basis of a 'genetic bottleneck' imposed every time a new person is infected. The findings define a window of opportunity for drugs or vaccines to prevent or limit infection. HIV represents evolution on overdrive. Every infected individual contains a swarm of viruses that exhibit variability in their RNA sequence, and new mutations are constantly appearing. Yet nearly every time someone ...
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